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Despite the significant personal and societal impact associated with limb difference, limb preservation, and limb loss, there is little current evidence on effective clinical practices and technologies in this field. Published research studies rely on either administrative data sources, hospital discharge statistics, or small single-center studies with limited longitudinal follow-up. Although limb loss is a common outcome measure in studies that evaluate the effectiveness of diabetes and peripheral arterial disease care, little is known about the effectiveness of practices and technologies following a limb loss or a limb preservation surgery.
