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Home News

Stem Cell Treatment May Reduce PAD-Related Amputations

by The O&P EDGE
May 4, 2012
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Research led by vascular surgeons at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, may offer new hope to sufferers of peripheral artery disease (PAD), the cause of nearly 60,000 lower-limb amputations annually, through the use of a patient’s own stem cells.

Richard J. Powell, MD, chief of vascular surgery at Dartmouth-Hitchcock, is the principal investigator on a national study involving 550 patients at 80 sites around the country of so-called “no option” patients for whom the disease is so advanced that amputation is the only available treatment. His study is now in a three-year, third-stage clinical trial, after second-stage trials showed success at treating patients with chronic limb ischemia (CLI). The final results of the second-stage clinical trial have been published in the April 2012 issue of Molecular Therapy.

In many PAD cases, endovascular therapies such as insertion of stents or bypass surgery are used to reintroduce blood flow to the legs. But in about 150,000 patients with the most-severe forms of PAD, called CLI, the disease is so extensive that endovascular therapy isn’t an option. That’s where Powell’s stem cell study comes in.

“All of us have stem cells in our bone marrow, and these stem cells can be utilized to repair other parts of our bodies,” said Powell, in a Dartmouth-Hitchcock press release. “By taking the patient’s own stem cells and injecting them into the ischemic leg, our hope is that we will then improve the blood flow in that part of the leg.”

In the study, bone marrow is removed from the patient’s hip, and then sent to a lab where stem cells are separated from the marrow and incubated over a two-week period, allowing more stem cells to grow. The stem cells are then re-injected intramuscularly into about 20 different spots on the patient’s leg. After six months of the second-stage trials, approximately half of the patients who received a placebo died, required an amputation, or saw their leg wounds worsen. Of those receiving the stem cell therapy, only a quarter died, required amputation, or saw their wounds worsen. Many showed significant improvement in blood flow in the ischemic limb.

“What was truly remarkable was that it was a relatively small number of patients, but that we saw clinically significant improvement in the stem cell-treated patients,” Powell said. “It’s compelling enough that there’s no question that the pivotal trial needs to be done as quickly as possible.”

The phase three trial has recently begun, in which half of the patients will receive stem cell therapy and half will receive the placebo, measuring incidents of amputation or death one year after the treatment “We really want to see a therapy that’s effective out to a year,” said Powell. “Nonetheless, the results so far are really promising.”

Related posts:

  1. PLX-PAD: Stem Cell Treatment May Save Limbs
  2. UC Davis Launches Study to Reduce Amputations from Vascular Disease, Diabetes
  3. Study Sheds Light on Stem Cell Role in Regenerating Fingers, Toes
  4. Risk Prediction Equations for Lower-limb Amputation: The Changing Face of Healthcare
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