Pediatric O&P is a subspecialty of our profession that can be fulfilling, albeit demanding and challenging—especially as it pertains to the orthotic management of infants. While it may appear that an infant, particularly an infant in the neonatal intensive care unit (NICU), would be easier to manage orthotically, since gait analysis is not applicable and x-rays may not be necessary, the opposite is frequently true. This population offers an entirely new set of considerations and issues. Patient size, homeostasis, and essential medical equipment can create unique challenges. As a result, it is important that the treatment plan be tailored to this population.