When a person loses a hand to amputation, nerves that control sensation and movement are severed, causing changes in areas of the brain that controlled these functions. As a result, areas of the brain devoted to the missing hand take on other functions. Now, researchers from the University of Missouri have found evidence of specific neurochemical changes associated with lower neuronal health in these brain regions. Further, they reported that some of these changes in the brain may persist in individuals who receive hand transplants, despite their recovered hand functions.
“When there is a sudden increase or decrease in stimulation that the brain receives, the function and structure of the brain begins to change,” said Carmen M. Cirstea, MD, PhD, research assistant professor of physical medicine and rehabilitation and lead author of the study. “Using a noninvasive approach known as magnetic resonance spectroscopy (MRS) to examine areas of the brain previously involved with hand function, we observed the types of changes taking place at the neurochemical level after amputation, transplantation, or reattachment.”
Because only five patients who had undergone reattachments or transplants were studied, the researchers suggested that the results should be interpreted with caution until more work is completed.
The study, “Magnetic Resonance Spectroscopy of Current Hand Amputees Reveals Evidence for Neuronal-level Changes in Former Sensorimotor Cortex,” was published in the April issue of Journal of Neurophysiology.
Editor’s note: This story was adapted from materials provided by the University of Missouri Health School of Medicine.