A growing number of individuals with upper-limb loss are electing to use their prostheses as a means of self-expression. An anatomically realistic prosthesis may still be ideal for many, but tattoos, custom artwork, bright colors, patterns, and even the raw display of the upper-limb prosthetic device’s mechanical components is becoming more prominent and accepted. Patients may elect to incorporate artwork onto their prostheses for a variety of reasons, and the options for such customizations are increasing. For individuals with limb loss, customization of their prostheses can create a greater sense of control, personal connection to themselves and others, and, ultimately, acceptance. This article introduces the topic of self-expression and the positive clinical impact it can have for the prosthetic patient population.